[Polymorphism of the IL1RN gene in Spanish patients with ulcerative colitis].

Abstract

BACKGROUND:

The etiology of the inflammatory bowel disease is unknown. Previous studies have shown an association between the allele 2 of IL1RN, the gene that encodes for the interleukin 1 receptor antagonist (IL-1ra), and the inflammatory bowel disease.

PATIENTS AND METHODS:

We have analyzed the incidence of the IL1RN alleles in 41 patients with ulcerative colitis and in 40 healthy subjects.

RESULTS:

Our results show the same allelic distribution between the subjects with ulcerative colitis and the healthy population.

CONCLUSIONS:

These results suggest that the allelic variants of the VNTR of the IL-1ra gene are not associated to a higher susceptibility to ulcerative colitis in Spanish population.

• Authors: R González Sarmiento, P Araoz, R Rodríguez, A Oliveira, I Feranández Blanco, A Sánchez Rodríguez
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 112 Issue 20 Pg. 778-9 (Jun 05 1999) ISSN: 0025-7753 [Print] Spain
• Vernacular Title: Estudio de polimorfismos del gen IL1RN en pacientes españoles con colitis ulcerosa.
• PMID: 10422059 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• IL1RN protein, human
• Interleukin 1 Receptor Antagonist Protein
• Receptors, Interleukin-1
• Sialoglycoproteins

Topics

• Adolescent
• Adult
• Colitis, Ulcerative (genetics)
• Female
• Humans
• Interleukin 1 Receptor Antagonist Protein
• Male
• Middle Aged
• Polymorphism, Genetic
• Receptors, Interleukin-1 (antagonists & inhibitors)
• Sialoglycoproteins (genetics)
• Spain