Abstract |
Recurrent acyclovir (ACV)-resistant (ACV-r) herpes simplex virus type 1 (HSV-1) infections occurred in a patient with Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency syndrome composed of three clinical characteristics of immunodeficiency, thrombocytopenia, and an eczematous dermatitis. The patient had severe and recurrent ACV-r herpes simplex and was treated with vidarabine in a satisfactory manner from 1993 to 1997. During the 4-year observation period, two ACV-sensitive (ACV-s) HSV-1 isolates and five ACV-r HSV-1 isolates were recovered. The nucleotide sequence of the thymidine kinase (TK) gene from these sequential ACV-r isolates was compared with the ACV-s isolates. A single nucleotide deletion of cytosine (C) from homopolymer stretch of four C residues between nucleotide 1061 and 1064 of the open reading frame was found in all ACV-r isolates. No other differences were observed in the TK nucleotide sequence between ACV-s and ACV-r isolates. The TK nucleotide sequences of the two ACV-s isolates were identical to each other and those of the five ACV-r isolates were identical to one another. These results suggest that the ACV-r HSV-1 might have derived from the ACV-s strain in the patient body and that TK-associated ACV-r HSV-1 can reactivate from latency.
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Authors | M Saijo, T Suzutani, K Itoh, Y Hirano, K Murono, M Nagamine, K Mizuta, M Niikura, S Morikawa |
Journal | Journal of medical virology
(J Med Virol)
Vol. 58
Issue 4
Pg. 387-93
(Aug 1999)
ISSN: 0146-6615 [Print] United States |
PMID | 10421406
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antiviral Agents
- DNA, Viral
- Thymidine Kinase
- Acyclovir
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Topics |
- Acyclovir
(therapeutic use)
- Amino Acid Sequence
- Antiviral Agents
(therapeutic use)
- Base Sequence
- Child
- DNA, Viral
(chemistry, genetics)
- Drug Resistance, Microbial
- Follow-Up Studies
- Genetic Variation
- Herpes Simplex
(complications, virology)
- Herpesvirus 1, Human
(drug effects, genetics, isolation & purification)
- Humans
- Japan
- Male
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Phosphorylation
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Thymidine Kinase
(genetics)
- Wiskott-Aldrich Syndrome
(complications)
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