Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1.

Abstract

Almost any growth of tumors is to some extent associated with an inflammatory reaction which may be anti-tumorigenic by acting directly on tumor cells or protumorigenic cells presumably by inducing tumor-associated angiogenesis. In this study, we have analyzed the angiogenesis-inducing capacity of monocyte chemoattractant protein-1 (MCP-1), a key regulatory molecule of monocyte trafficking to sites of inflammation. MCP-1 was found to be potently angiogenic when implanted into rabbit cornea, exerting potency similar to the specific angiogenic vascular endothelial growth factor (VEGF)-A(121). MCP-1-induced angiogenesis in the cornea is associated with prominent recruitment of macrophages, whereas VEGF-A(121)-induced corneal angiogenesis is devoid of inflammatory cell recruitment. Based on these findings, we studied MCP-1 expression and macrophage recruitment in human invasive ductal mammary carcinomas in comparison with the physiological angiogenic processes in bovine ovarian corpus luteum. Macrophage recruitment was always associated with MCP-1 expression. High macrophage counts in mammary tumors corresponded with poor prognosis. In contrast, physiological ovarian angiogenesis was associated with only minimal inflammatory recruitment of macrophages. Our data show that MCP-1 is an indirect inflammation-associated inducer of angiogenesis and demonstrate distinct qualitative differences between tumor angiogenesis in human mammary tumors and physiological angiogenesis in the ovary.

• Authors: V Goede, L Brogelli, M Ziche, H G Augustin
• Journal: International journal of cancer (Int J Cancer) Vol. 82 Issue 5 Pg. 765-70 (Aug 27 1999) ISSN: 0020-7136 [Print] United States
• PMID: 10417778 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 1999 Wiley-Liss, Inc.

Chemical References

• Chemokine CCL2
• Endothelial Growth Factors
• Lymphokines
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors

Topics

• Animals
• Breast Neoplasms (blood supply, pathology)
• Carcinoma, Ductal, Breast (blood supply, pathology)
• Cattle
• Chemokine CCL2 (physiology)
• Cornea (blood supply)
• Corpus Luteum (blood supply, pathology)
• Endothelial Growth Factors (physiology)
• Female
• Humans
• Lymphokines (physiology)
• Macrophages (physiology)
• Neovascularization, Pathologic (physiopathology)
• Ovary (blood supply, pathology)
• Rabbits
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors