The effect of cyclic AMP on expression of the major immediate-early genes and replication of human cytomegalovirus in human central nervous system cell lines.

Abstract	The effect of dibutyryl cyclic AMP (dbcAMP) on interaction of human cytomegalovirus (HCMV) with human central nervous system cell lines was examined. Activation of the major immediate-early (IE) promoter (MIEP) of HCMV by dbcAMP was observed in human neuroblastoma IMR-32 cells, but not in glioma 118MGC and astrocytoma U373-MG cells. The 19 bp repeat element in the enhancer of the MIEP was most likely to be the cis-element that responded to dbcAMP in IMR-32 cells as we expected. In IMR-32 cells activation of the MIEP led to enhanced synthesis of the major IE proteins and infectious HCMV.
Authors	H Sadanari, R Yamada, J Tanaka, T Murayama, K Ohnishi, K Matsubara, S Fukuda
Journal	Archives of virology (Arch Virol) Vol. 144 Issue 5 Pg. 1015-25 ( 1999) ISSN: 0304-8608 [Print] Austria
PMID	10416383 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Immediate-Early Proteins Bucladesine Cyclic AMP
Topics	Astrocytoma Brain Neoplasms Bucladesine (pharmacology) Cell Line Cyclic AMP (metabolism) Cytomegalovirus (drug effects, genetics) Genes, Immediate-Early (drug effects) Genes, Viral (drug effects) Glioma Humans Immediate-Early Proteins (biosynthesis, genetics) Kinetics Lung Neuroblastoma Tumor Cells, Cultured Virus Replication (drug effects, physiology)

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