Protective effect of exogenous coenzyme Q in rats subjected to partial hepatic ischemia and reperfusion.

Abstract

In a surgical model of liver ischemia lipid peroxidation occurs, as shown by increase of lipid peroxidation end products, endogenous CoQ9 is oxidized and mitochondrial respiration is lowered; however, pre-treatment of the rats by i.p. injection of CoQ10 for 14 days normalizes the above parameters, presumably by way of the observed high extent of reduction of the incorporated quinone; moreover, liver homogenates of the CoQ10-treated rats are more resistant than those of non-treated rats to oxidative stress induced by an azido free radical initiator. This preliminary study suggests that CoQ10 pre-treatment can be of beneficial effect against oxidative damage during liver surgery transplantation.

• Authors: M L Genova, E Bonacorsi, M D'Aurelio, G Formiggini, B Nardo, S Cuccomarino, P Turi, M M Pich, G Lenaz, C Bovina
• Journal: BioFactors (Oxford, England) (Biofactors) Vol. 9 Issue 2-4 Pg. 345-9 ( 1999) ISSN: 0951-6433 [Print] Netherlands
• PMID: 10416051 (Publication Type: Journal Article)

Chemical References

• Amidines
• Antioxidants
• Oxidants
• Vitamin A
• Ubiquinone
• Vitamin E
• 2,2'-azobis(2-amidinopropane)

Topics

• Amidines (pharmacology)
• Animals
• Antioxidants (metabolism)
• Ischemia (physiopathology)
• Lipid Peroxidation (drug effects)
• Liver (blood supply, drug effects, metabolism)
• Oxidants (pharmacology)
• Rats
• Reperfusion
• Reperfusion Injury (prevention & control)
• Ubiquinone (analogs & derivatives, metabolism, pharmacology)
• Vitamin A (metabolism)
• Vitamin E (metabolism)