[The technology for manufacturing antiparasitic preparations. 9. The new preparation tizanox and an evaluation of its anti-Hymenolepis activity].

Abstract

The paper describes a procedure for manufacturing the new anthelminthic Tizanox. It shows it necessary to administer a larger dose of the drug than that of azinox (praziquantel) to treat experimental hymenolepiasis. However, the lower toxicity of Tizanox enhances its chemotherapeutical index.

• Authors: F S Mikhaĭlitsyn, N L Sergovskaia, N A Uvarova, B V Lopatin, G A Gitsu, B A Astaf'ev, M N Lebedeva, N D Lychko
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1999 Jan-Mar Issue 1 Pg. 49-51 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Tekhnologiia proizvodstva protivoparazitarnykh preparatov. 9. Novyĭ preparat tizanoks i otsenka ego protivogimenolepidoznoĭ aktivnosti.
• PMID: 10414049 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticestodal Agents
• Isoquinolines
• Thiadiazines
• azinox
• tizanox
• Praziquantel

Topics

• Animals
• Anticestodal Agents (analysis, chemical synthesis, therapeutic use, toxicity)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Hymenolepiasis (drug therapy)
• Isoquinolines (analysis, chemical synthesis, therapeutic use, toxicity)
• Mice
• Praziquantel (analogs & derivatives, therapeutic use, toxicity)
• Spectrophotometry, Infrared (statistics & numerical data)
• Thiadiazines (analysis, chemical synthesis, therapeutic use, toxicity)