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Recurrence rate of hirsutism after 3 different antiandrogen therapies.

AbstractBACKGROUND:
Although antiandrogens are frequently and successfully used to treat hirsutism, little attention has been paid to optimal duration of treatment and recurrence rate after cessation of therapy.
OBJECTIVE:
Our purpose was to determine the recurrence rate of hirsutism after 3 different antiandrogen therapies.
METHODS:
Eighty-one hirsute women referred to a tertiary hirsutism clinic were assigned to one of three regimens: spironolactone 100 mg/day with an oral contraceptive, cyproterone acetate 50 mg/day on days 1 to 10 with an oral contraceptive, or flutamide 250 mg twice a day. Hirsutism scores according to the Ferriman-Gallwey scoring system and endocrine parameters were evaluated before, during, and 1 year after withdrawal of treatment regimens.
RESULTS:
Hirsutism scores decreased significantly and similarly in spironolactone, flutamide, and cyproterone acetate treatment groups. However, 1 year after withdrawal of treatment in all antiandrogen therapy groups, hirsutism returned.
CONCLUSION:
Antiandrogens are effective in the treatment of hirsutism. However, cessation of antiandrogen therapy is followed by recurrence.
AuthorsD Yücelten, M Erenus, O Gürbüz, F Durmuşoğlu
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 41 Issue 1 Pg. 64-8 (Jul 1999) ISSN: 0190-9622 [Print] United States
PMID10411413 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Androgen Antagonists
  • Contraceptives, Oral
  • Spironolactone
  • Testosterone
  • Flutamide
  • Luteinizing Hormone
  • Cyproterone
Topics
  • Androgen Antagonists (therapeutic use)
  • Contraceptives, Oral (therapeutic use)
  • Cyproterone (therapeutic use)
  • Female
  • Flutamide (therapeutic use)
  • Hirsutism (blood, drug therapy)
  • Humans
  • Luteinizing Hormone (blood)
  • Recurrence
  • Spironolactone (therapeutic use)
  • Testosterone (blood)

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