Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells.

Abstract

In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of beta-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.

• Authors: J C Medina, D Roche, B Shan, R M Learned, W P Frankmoelle, D L Clark, T Rosen, J C Jaen
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 9 Issue 13 Pg. 1843-6 (Jul 05 1999) ISSN: 0960-894X [Print] England
• PMID: 10406652 (Publication Type: Journal Article)

Chemical References

• Growth Inhibitors
• Halogens
• Sulfonamides

Topics

• Drug Resistance, Multiple
• Growth Inhibitors (chemical synthesis, pharmacology)
• Halogens (chemistry)
• HeLa Cells
• Humans
• Sulfonamides (chemical synthesis, pharmacology)
• Tumor Cells, Cultured