Detection of preclinical Parkinson disease in at-risk family members with use of [123I]beta-CIT and SPECT: an exploratory study.

Abstract

OBJECTIVE:

To explore whether the radioligand 2 beta-carboxymethoxy-3 beta-(4-[123I] iodophenyl) tropane ([123I]beta-CIT) and single-photon emission computed tomography (SPECT) can detect decreased striatal uptake in at-risk relatives of patients with Parkinson disease (PD).

PATIENTS AND METHODS:

Ten PD patients, 10 at-risk first-degree relatives of PD patients, and 10 controls underwent [123I]beta-CIT and SPECT brain imaging. Their striatal uptake ratios were compared.

RESULTS:

Age-adjusted specific to nonspecific striatal uptake ratios were lower in patients compared with controls and with relatives; however, ratios were similar in relatives and controls. Among relatives, ratios were consistently lower in subgroups postulated to be at higher risk for preclinical PD.

CONCLUSION:

Our findings provide preliminary support that [123I]beta-CIT and SPECT may detect decreased striatal uptake in relatives of PD patients postulated to be at higher risk for PD.

• Authors: D M Maraganore, M K O'Connor, J H Bower, K M Kuntz, S K McDonnell, D J Schaid, W A Rocca
• Journal: Mayo Clinic proceedings (Mayo Clin Proc) Vol. 74 Issue 7 Pg. 681-5 (Jul 1999) ISSN: 0025-6196 [Print] England
• PMID: 10405696 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Iodine Radioisotopes
• 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
• Cocaine

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Case-Control Studies
• Cocaine (analogs & derivatives)
• Corpus Striatum (diagnostic imaging)
• Female
• Humans
• Iodine Radioisotopes
• Male
• Middle Aged
• Parkinson Disease (diagnostic imaging)
• Risk
• Tomography, Emission-Computed (methods)
• Tomography, Emission-Computed, Single-Photon (methods)