Abstract |
The neurodevelopmental outcome of very low birth weight infants experiencing early-onset intraventricular hemorrhage (IVH) occurring within the first 6 postnatal hours was compared with that of their peers without early-onset IVH at 3 years corrected age. The 440 surviving preterm infants ( birth weight 600 to 1,250 g) who had been enrolled in a multicenter, prospectively randomized, controlled trial evaluating the efficacy of postnatal indomethacin to prevent IVH were evaluated with the Stanford-Binet Intelligence Scale and neurological examinations at 3 years corrected age. All study infants had echoencephalography between 5 and 11 hours of life, and testing is reported for all children residing in English monolingual households at 3 years corrected age (i.e., from the obstetric due date). Fifty five of the 73 (75%) infants with IVH within the first 5 to 11 hours survived to 3 years of age, compared with 385 of the 432 (89%) children without early-onset hemorrhage who were alive at 3 years corrected age (P<.001). Eleven of the 29 (38%) English monolingual children with early-onset IVH had Stanford-Binet intelligence quotient scores of less than 70, compared with 47 of the 249 (19%) children without early IVH (P = .03). Similarly, 7 of 28 (25%) early IVH children were found to have cerebral palsy, compared with 20 of 241 (8%) children without early IVH (P = .01). These data suggest that infants who experience the early onset of IVH are at high risk for both cognitive and motor handicaps at 3 years corrected age.
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Authors | B Vohr, W C Allan, D T Scott, K H Katz, K C Schneider, R W Makuch, L R Ment |
Journal | Seminars in perinatology
(Semin Perinatol)
Vol. 23
Issue 3
Pg. 212-7
(Jun 1999)
ISSN: 0146-0005 [Print] United States |
PMID | 10405190
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Aging
- Brain Diseases
(epidemiology, etiology)
- Cerebral Hemorrhage
(complications, diagnostic imaging, prevention & control)
- Cerebral Palsy
(epidemiology, etiology)
- Humans
- Indomethacin
(therapeutic use)
- Infant, Newborn
- Infant, Very Low Birth Weight
- Intelligence Tests
- Prospective Studies
- Ultrasonography
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