Therapy of difficult cases of canine pyoderma with marbofloxacin: a report of 39 dogs.

Abstract

Thirty-nine dogs with severe and/or recurrent lesions of pyoderma were treated with marbofloxacin at an average dosage of 2.12 mg/kg bodyweight, once daily, for time periods varing from 10 to 213 days. Forty-seven strains of bacteria, isolated from 34 cultures, were tested for sensitivity to various antibiotics. At day 0, no resistance to marbofloxacin was found, but one refractory case, a strain of Staphylococcus intermedius resistant to marbofloxacin, was cultured at day 28. Thirty-three dogs (84.6 per cent) showed an excellent response (cure), one (2.6 per cent) a clear improvement and one (2.6 per cent) a smaller improvement, while the remaining four dogs showed no response after 11 to 60 days. Fifteen dogs (45.5 per cent) relapsed over the follow-up period of three to 191 days, but none of the dogs in the study exhibited any adverse effects.

• Authors: D N Carlotti, E Guaguere, D Pin, P Jasmin, E Thomas, V Guiral
• Journal: The Journal of small animal practice (J Small Anim Pract) Vol. 40 Issue 6 Pg. 265-70 (Jun 1999) ISSN: 0022-4510 [Print] England
• PMID: 10404486 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Infective Agents
• Enzyme Inhibitors
• Fluoroquinolones
• Quinolones
• marbofloxacin

Topics

• Animals
• Anti-Infective Agents (administration & dosage)
• Body Weight
• Cellulitis (drug therapy, microbiology, veterinary)
• Dog Diseases (drug therapy)
• Dogs
• Enzyme Inhibitors (administration & dosage)
• Erythema (drug therapy, microbiology, veterinary)
• Female
• Fluoroquinolones
• Folliculitis (drug therapy, microbiology, veterinary)
• Follow-Up Studies
• Male
• Microbial Sensitivity Tests
• Pruritus (drug therapy, microbiology, veterinary)
• Pyoderma (drug therapy, microbiology, veterinary)
• Quinolones (administration & dosage)
• Recurrence
• Skin Ulcer (drug therapy, microbiology, veterinary)
• Staphylococcal Infections (drug therapy)
• Treatment Outcome