Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses.

Abstract

Tumor-associated carbohydrate (TAC) antigens are important targets in cancer vaccine efforts. Carbohydrates are, however, frequently poor immunogens, in that they are T-cell-independent antigens. Molecular mimicry of TAC by peptides is an alternative approach to generating anti-carbohydrate immune responses. Here we demonstrate that peptide mimotopes can elicit antibody responses that cross-react with representative human TAC antigens. Primary immunization with such a multiple antigenic peptide, along with QS-21 as adjuvant, elicits cytotoxic antibodies reactive with naturally occurring forms of TAC expressed on tumor cells, and vaccination of mice with peptide mimotopes reduced tumor growth and prolonged host survival in a murine tumor model.

• Authors: T Kieber-Emmons, P Luo, J Qiu, T Y Chang, I O, M Blaszczyk-Thurin, Z Steplewski
• Journal: Nature biotechnology (Nat Biotechnol) Vol. 17 Issue 7 Pg. 660-5 (Jul 1999) ISSN: 1087-0156 [Print] United States
• PMID: 10404158 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies
• Antigens, Tumor-Associated, Carbohydrate
• Cancer Vaccines
• Lewis Blood Group Antigens
• Peptides
• peptide 106
• Complement System Proteins

Topics

• Amino Acid Sequence
• Animals
• Antibodies (blood)
• Antigens, Tumor-Associated, Carbohydrate (immunology)
• Cancer Vaccines (immunology, therapeutic use)
• Complement System Proteins (immunology)
• Cytotoxicity, Immunologic
• Flow Cytometry
• Humans
• Lewis Blood Group Antigens (immunology)
• Mice
• Mice, Inbred BALB C
• Molecular Mimicry
• Molecular Sequence Data
• Peptides (chemical synthesis, chemistry, immunology)
• Sarcoma, Experimental (chemically induced, immunology, therapy)
• Tumor Cells, Cultured
• Vaccination