Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia.

Abstract

We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D1, cuphiin D2, oenothein B and woodfordin C isolated from Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin against a normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC50 = 11.4 microg/ml) against S-180 tumor cells in culture, while cuphiin D1 resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS = 84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications.

• Authors: C C Wang, L G Chen, L L Yang
• Journal: Cancer letters (Cancer Lett) Vol. 140 Issue 1-2 Pg. 195-200 (Jun 01 1999) ISSN: 0304-3835 [Print] Ireland
• PMID: 10403559 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Hydrolyzable Tannins
• Tannins
• cuphiin D(1)
• cuphiin D(2)
• oenothein B
• woodfordin C

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• Body Weight (drug effects)
• Cell Division (drug effects)
• Drug Evaluation, Preclinical
• Humans
• Hydrolyzable Tannins
• Male
• Mice
• Mice, Inbred ICR
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy, mortality, pathology)
• Survival Rate
• Tannins (pharmacology, therapeutic use)
• Tumor Cells, Cultured
• Tumor Stem Cell Assay