Short report: prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide.

Abstract

N,N-diethyl-3-methylbenzamide (DEET) has recently been reported to kill cercariae of Schistosoma mansoni in vitro. In addition, it blocked cercarial entry into mouse tail skin. We confirmed these results and compared the efficacy of DEET to a second insect repellent, 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), in preventing S. mansoni infections in mice. Both AI3-37220 and DEET conferred 100% protection against S. mansoni infection via percutaneous exposure to cercariae.

• Authors: W E Secor, G L Freeman Jr, R A Wirtz
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 60 Issue 6 Pg. 1061-2 (Jun 1999) ISSN: 0002-9637 [Print] United States
• PMID: 10403344 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Insect Repellents
• Piperidines
• DEET
• 1-(3-cyclohexen-1-ylcarbonyl)-2-methylpiperidine

Topics

• Animals
• DEET (pharmacology, therapeutic use)
• Insect Repellents (pharmacology, therapeutic use)
• Intestines (parasitology)
• Liver (parasitology)
• Male
• Mice
• Mice, Inbred CBA
• Piperidines (pharmacology, therapeutic use)
• Schistosoma mansoni (drug effects)
• Schistosomiasis mansoni (prevention & control)
• Skin (drug effects)