[Neurotrophic action of nicotinamide and nicotinoyl-GABA in rat brain in experimental Parkinsonism].

Abstract

It was established, that the content of nicotinamide adenine dinucleotides and the binding of NAD by isolated brain cortex synaptic membranes under experimental parkinsonism are impaired. Treatment of the experimental results in the Scatchard plots for binding of [U-14C]NAD to the brain cortex synaptic membranes demonstrated that binding capacities lowered, without changes of affinities. NAD-glycohydrolase involved in development of this pathology. The modulative effect of in vivo administered NAm and nicotinoyl-GABA supposes that NAm acts via NAD which binds specifically with synaptic membranes. Thus, NAm and nicotinoyl-GABA are involved in the regulation of the processes in the brain under experimental parkinsonism.

• Authors: T M Kuchmerovs'ka
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1998 Nov-Dec Vol. 70 Issue 6 Pg. 126-31 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Neĭrotropna diia nikotynamidu ta nikotynoïl-gamma-aminomaslianoï kysloty u holovnomu mozku pry eksperymental'nomu Parkinsonizmi shchuriv.
• PMID: 10402661 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbon Radioisotopes
• NAD
• gamma-Aminobutyric Acid
• NAD+ Nucleosidase

Topics

• Animals
• Carbon Radioisotopes
• Cerebral Cortex (enzymology, metabolism)
• Male
• NAD (metabolism)
• NAD+ Nucleosidase (metabolism)
• Parkinson Disease, Secondary (metabolism)
• Radioligand Assay
• Rats
• Rats, Wistar
• Synaptic Membranes (metabolism)
• gamma-Aminobutyric Acid (metabolism)