The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy").

Abstract

Administration of a single dose of the recreationally used drug 3,4-methylenedioxyethamphetamine (MDEA or "eve") to Dark Agouti rats resulted in an acute dose-dependent hyperthermic response. The peak effect and duration of hyperthermia of a dose of MDEA of 35 mg/kg intraperitoneally was similar to a dose of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") of 15 mg/kg intraperitoneally. Seven days later this dose of MDMA produced a marked (approximately 50%) loss of 5-HT and its metabolite 5-HIAA in cortex, hippocampus and striatum and a similar loss of [3H]-paroxetine binding in cortex: these losses reflecting the MDMA-induced neurotoxic degeneration of 5-HT nerve endings. In contrast, administration of MDEA (15, 25 or 35 mg/kg), even at the highest dose, produced only a 20% loss in cortex and hippocampus and no decrease in striatum. The neurotoxic effect of MDEA was only weakly dose-dependent. Neither MDEA (35 mg/kg) nor MDMA (15 mg/kg) altered striatal dopamine content 7 days later. MDEA appeared to have about half the potency of MDMA in inducing acute hyperthermia and 25% of the potency in inducing degeneration of cerebral 5-HT neurones. However since higher doses of MDEA (compared to MDMA) are probably necessary to induce mood changing effects, these data do not support any contention that this compound is a "safer" recreational drug than MDMA in terms of either acute toxicity or long term neurodegeneration.

• Authors: M I Colado, R Granados, E O'Shea, B Esteban, A R Green
• Journal: Pharmacology & toxicology (Pharmacol Toxicol) Vol. 84 Issue 6 Pg. 261-6 (Jun 1999) ISSN: 0901-9928 [Print] Denmark
• PMID: 10401727 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amphetamines
• Serotonin
• Paroxetine
• 3,4-Methylenedioxyamphetamine
• N-Methyl-3,4-methylenedioxyamphetamine
• 3,4-methylenedioxyethamphetamine

Topics

• 3,4-Methylenedioxyamphetamine (analogs & derivatives, toxicity)
• Amphetamines (toxicity)
• Animals
• Brain (drug effects, metabolism)
• Cerebral Cortex (drug effects, metabolism)
• Dose-Response Relationship, Drug
• Fever (chemically induced)
• Hippocampus (drug effects, metabolism)
• Male
• N-Methyl-3,4-methylenedioxyamphetamine (toxicity)
• Nerve Endings (drug effects)
• Paroxetine (analysis)
• Rats
• Serotonin (analysis)
• Time Factors
• Visual Cortex (drug effects, metabolism)