Abstract | BACKGROUND: OBJECTIVE AND METHODS: RESULTS: We found 67 subjects with IgG subclass deficiency, 21 subjects with mild (partial) and 5 with usual common variable immunodeficiency, and 2 subjects with functional IgG deficiency. Atopy was encountered in 42/95 subjects, 33/44 (75%) with asthma, 7/19 (38%) with isolated rhinosinusitis, 1/27 (4%) with chronic obstructive lung disease, and 1/5 (20%) with both the latter disease and asthma, respectively. Atopy was preferentially clustered in subjects with asthma (P < .05) who were less than 40 years of age (P < .05) and nonsmoking. Atopy was not affected by the type of IgG deficiency, unless it was usual common variable immunodeficiency, in which case the skin tests tended to be negative (4/5). Total IgE was within normal range but less elevated than usually seen in asthma or chronic obstructive lung disease. Total IgE was independent of the type of IgG deficiency, except for usual common variable immunodeficiency in which it remained < 10 IU/mL. CONCLUSIONS:
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Authors | V Popa, S M Nagy Jr |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 82
Issue 6
Pg. 567-73
(Jun 1999)
ISSN: 1081-1206 [Print] United States |
PMID | 10400485
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Asthma
(immunology)
- Humans
- Hypersensitivity, Immediate
(complications, epidemiology)
- IgG Deficiency
(complications)
- Immunoglobulin E
(analysis, deficiency)
- Lung Diseases, Obstructive
(immunology)
- Prevalence
- Reference Values
- Respiratory Tract Infections
(immunology)
- Rhinitis
(immunology)
- Sinusitis
(immunology)
- Skin Tests
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