Abstract | BACKGROUND: OBJECTIVE: METHODS: Following a 1- to 2-week washout period, patients were randomized to 7 days of double-blind treatment with either azelastine nasal spray (2 sprays per nostril bid, 1.1 mg/day) monotherapy or combination therapy with oral loratadine ( Claritin, one 10-mg tablet/day) plus intranasal beclomethasone dipropionate monohydrate ( Beconase AQ, 2 sprays per nostril bid, 336 microg/day). Efficacy was determined at the end of the study by both a physician assessment of the need for additional anti- rhinitis medication and a patient global evaluation of therapeutic effectiveness. The three studies were conducted at 71 investigational sites during the 1998 spring allergy season. Three separate studies were conducted to verify the reproducibility of the new study design. RESULTS: CONCLUSIONS:
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Authors | W E Berger, S M Fineman, P Lieberman, R M Miles |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 82
Issue 6
Pg. 535-41
(Jun 1999)
ISSN: 1081-1206 [Print] United States |
PMID | 10400480
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Histamine H1 Antagonists
- Lipoxygenase Inhibitors
- Phthalazines
- Tablets
- Loratadine
- Beclomethasone
- azelastine
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Topics |
- Administration, Intranasal
- Adolescent
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage, adverse effects, pharmacokinetics)
- Beclomethasone
(administration & dosage, adverse effects, pharmacokinetics)
- Child
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Headache
(chemically induced)
- Histamine H1 Antagonists
(administration & dosage, adverse effects, pharmacokinetics)
- Humans
- Lipoxygenase Inhibitors
(administration & dosage, adverse effects, pharmacokinetics)
- Loratadine
(administration & dosage, adverse effects, pharmacokinetics)
- Male
- Middle Aged
- Phthalazines
(administration & dosage, adverse effects, pharmacokinetics)
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Tablets
- Taste
(drug effects)
- Therapeutic Equivalency
- Time Factors
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