The antibacterial activity of plaunotol against Staphylococcus aureus isolated from the skin of patients with atopic dermatitis.

Abstract

Plaunotol was tested for possible antibacterial activity against twenty strains of methicillin-resistant Staphylococcus aureus (MRSA) and fourteen strains of methicillin-sensitive S. aureus (MSSA) which had been isolated from the skin of patients with atopic dermatitis under growth-promoting conditions. Plaunotol was effective against all strains tested. The dose of plaunotol for 50% inhibition of growth (ID50) ranged from 2.5 to 16 micrograms/ml for strains of MRSA and from 2.5 to 7.0 micrograms/ml for those of MSSA. These results suggest that plaunotol may be useful in the prevention of infection by MRSA and in skin care for patients with atopic dermatitis.

• Authors: Y Matsumoto, H Hamashima, K Masuda, K Shiojima, M Sasatsu, T Arai
• Journal: Microbios (Microbios) Vol. 96 Issue 385 Pg. 149-55 ( 1998) ISSN: 0026-2633 [Print] England
• PMID: 10399344 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Diterpenes
• Fatty Alcohols
• plaunotol
• Methicillin

Topics

• Anti-Bacterial Agents (pharmacology)
• Dermatitis, Atopic (microbiology)
• Diterpenes
• Drug Resistance, Microbial
• Fatty Alcohols (pharmacology)
• Humans
• Methicillin (pharmacology)
• Skin (microbiology)
• Staphylococcus aureus (drug effects, growth & development)