Abstract |
The use of acetylated phenyl 1-seleno-beta-D-galactofuranoside as a glycosyl donor for the synthesis of protected D-Galf-beta-(1-->3)-alpha-D-Manp as its methyl or ethylthio glycoside has been demonstrated. Activation of the selenoglycoside over a thioglycoside acceptor by NIS/TfOH is extremely selective and gives the ethylthio disaccharide in 91% yield. The parent disaccharide is found as a terminal and branched unit in the lipopeptidophosphoglycan oligosaccharides of the protozoan Trypanosoma cruzi, the causative agent of Chagas' disease.
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Authors | B D Johnston, B M Pinto |
Journal | Carbohydrate research
(Carbohydr Res)
Vol. 315
Issue 3-4
Pg. 356-60
(Feb 28 1999)
ISSN: 0008-6215 [Print] Netherlands |
PMID | 10399306
(Publication Type: Corrected and Republished Article, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Disaccharides
- Organoselenium Compounds
- phenyl 1-selenogalactofuranoside
- Galactose
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Topics |
- Animals
- Carbohydrate Sequence
- Disaccharides
(chemical synthesis)
- Galactose
(chemistry)
- Molecular Sequence Data
- Organoselenium Compounds
(chemistry)
- Trypanosoma cruzi
(chemistry)
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