Abstract |
This case documents the association of ectopic pancreatic tissue with a duodenal somatostatinoma in a patient with type I neurofibromatosis. Pancreatic ducts have been noted within the centres of somatostatinomas, but little significance has been attached to this finding. Here we describe a patient in whom a separate proliferation of somatostatin cells occurred in association with the ectopic pancreatic ductular epithelium. This lesion bore a striking resemblance to the ductulo-insular or ductulo-endocrine complexes that are seen in nesidioblastosis in the pancreas. We therefore postulate that the ducts, which are sequestered within somatostatinomas, are of pathogenetic significance. The somatostatin-producing cells arise from these ducts, very much in the fashion of ductulo-endocrine complexes in nesidioblastosis.
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Authors | R Chetty, A Essa |
Journal | Pathology
(Pathology)
Vol. 31
Issue 2
Pg. 95-7
(May 1999)
ISSN: 0031-3025 [Print] England |
PMID | 10399162
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Ampulla of Vater
(pathology)
- Choristoma
(complications, pathology)
- Duodenal Neoplasms
(complications, pathology)
- Fatal Outcome
- Humans
- Male
- Neoplasms, Multiple Primary
(complications, pathology)
- Neurofibromatosis 1
(complications, pathology)
- Pancreas
- Somatostatinoma
(complications, pathology)
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