Effects of Sho-seiryu-to on experimental allergic rhinitis in guinea pigs.

Abstract

The effects of Sho-seiryu-to, an antiallergic Kampo medicine, on experimental allergic rhinitis were investigated in actively sensitized guinea pigs. The number of sneezes and scratches by the animals after a topical antigen challenge was significantly inhibited by pretreatment with Sho-seiryu-to (1000 mg/kg per os p.o.). The antigen-induced eosinophil infiltration in the nasal mucosa was significantly inhibited by Sho-seiryu-to (1000 mg/kg p.o.). Sho-seiryu-to (100 mg/kg p.o.) also reduced the increase in dye leakage to the nasal cavity induced by the antigen challenge and the antigen-induced decrease in volume of the nasal cavity was inhibited. Moreover, Sho-seiryu-to (1000 mg/kg p.o.) suppressed the volume change in the nasal cavity induced by leukotriene D4. These results demonstrate that Sho-seiryu-to inhibits experimental allergic rhinitis in guinea pigs, confirming that the agent may be beneficial for the treatment of allergic rhinitis.

• Authors: M Sakaguchi, A Mase, Y Ikeda, A Iizuka, S Imamura, Y Komatsu, K Ukai, Y Sakakura
• Journal: Methods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 21 Issue 4 Pg. 303-8 (May 1999) ISSN: 0379-0355 [Print] Spain
• PMID: 10399140 (Publication Type: Journal Article)

Chemical References

• Antigens
• Coloring Agents

Topics

• Animals
• Antigens (adverse effects, immunology)
• Behavior, Animal (drug effects)
• Cell Migration Inhibition
• Coloring Agents (pharmacokinetics)
• Eosinophils (drug effects)
• Guinea Pigs
• Male
• Nasal Mucosa (drug effects, immunology, pathology)
• Phytotherapy
• Plants, Medicinal (immunology, therapeutic use)
• Rhinitis, Allergic, Perennial (drug therapy)