Lung local defense in experimental diabetes mellitus and the effect of 11,20-dihydroxyecdysone in combination with maninil.

Abstract

Disorders of lung local defensive mechanisms were noted in rats with alloxane-induced diabetes mellitus, which showed itself as neutrophilic infiltration and decrease of macrophagal bactericidal action in the lungs. All this contributed to the development and chronization of bronchopulmonary inflammatory diseases. Use of maninil caused further inhibition of cellular and humoral lung immunity indices. Addition of 11,20-dihydroxyecdysone (turkesterone) to the therapy resulted in positive changes in the lung defense mechanisms. Arch.

• Authors: D K Najmutdinova, Z Saatov
• Journal: Archives of insect biochemistry and physiology (Arch Insect Biochem Physiol) Vol. 41 Issue 3 Pg. 144-7 ( 1999) ISSN: 0739-4462 [Print] United States
• PMID: 10398337 (Publication Type: Journal Article)
• Copyright: Copyright 1999 Wiley-Liss, Inc.

Chemical References

• Hypoglycemic Agents
• Ecdysterone
• turkesterone
• Glyburide

Topics

• Animals
• Diabetes Mellitus, Experimental (drug therapy, immunology)
• Ecdysterone (analogs & derivatives, chemistry, pharmacology)
• Glyburide (therapeutic use)
• Hypoglycemic Agents (therapeutic use)
• Lung (drug effects, immunology)
• Molecular Structure
• Rats