Peripheral effects of centrally administered interleukin-1beta in mice in relation to its clearance from the brain into the blood and tissue distribution.

Abstract

Administration of interleukin IL-1 induces acute-phase response and inhibition of gastric secretion more efficiently when administered intracerebroventricularly (i.c.v.) than when the same dose of IL-1 is administered systemically. In this study we describe the pharmacokinetics of IL-1beta, administered centrally or systemically, in the serum or in peripheral tissues. IL-1beta administered i.c.v. resulted in higher peak IL-1beta concentrations, and lasted longer, than intravenous (i.v.) or intraperitoneal (i.p.) administration. Higher IL-1beta levels in the liver and heart were observed after i. c.v. administration (compared to the i.p. or i.v. route). Our data suggest that centrally injected IL-1 induces higher circulating and hepatic IL-1 levels and contributes to the fact that the i.c.v. route of administration is particularly effective in inducing a liver acute-phase response.

• Authors: E Di Santo, F Benigni, D Agnello, J D Sipe, P Ghezzi
• Journal: Neuroimmunomodulation (Neuroimmunomodulation) 1999 Jul-Aug Vol. 6 Issue 4 Pg. 300-4 ISSN: 1021-7401 [Print] Switzerland
• PMID: 10393516 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acute-Phase Proteins
• Interleukin-1
• Interleukin-6
• Serum Amyloid A Protein

Topics

• Acute-Phase Proteins (metabolism)
• Animals
• Brain (drug effects, metabolism)
• Injections, Intraperitoneal
• Injections, Intravenous
• Injections, Intraventricular
• Interleukin-1 (pharmacokinetics, pharmacology)
• Interleukin-6 (blood)
• Male
• Metabolic Clearance Rate
• Mice
• Mice, Inbred Strains
• Serum Amyloid A Protein (metabolism)
• Tissue Distribution