[Change in the sensitivity of influenza virus, replicating in the presence of rimantadine, to antiviral agents].

A variant obtained by a single passage of the initial FPV in the presence of 25 micrograms/ml rimantadine is more resistant to the drug than the parental virus. Sensitivity to rimantadine is higher in a variant obtained similarly by cell culture infection with rimantadine-resistant FPV. Potentiation of the antiviral effect of a combination of ribavirin (12-25 micrograms/ml) and rimantadine (0.1-6 micrograms/ml) is decreased or null if rimantadine dose is increased to 12-25 micrograms/ml; this phenomenon does not depend on the sensitivity of infective virus to rimantadine. Antiviral effect of drug combination with a high concentration of rimantadine is due to ribavirin alone.
AuthorsE I Boreko, N I Pavlova, V I Votiakov
JournalVoprosy virusologii (Vopr Virusol) 1999 May-Jun Vol. 44 Issue 3 Pg. 115-9 ISSN: 0507-4088 [Print] RUSSIA
Vernacular TitleIzmenenie chuvstvitel'nosti virusa grippa, razmnozhivshegosia v prisutstvii remantadina, k protivovirusnym preparatam.
PMID10392434 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antiviral Agents
  • Rimantadine
  • Ribavirin
  • Animals
  • Antiviral Agents (pharmacology)
  • Cells, Cultured
  • Chick Embryo
  • Drug Resistance, Microbial
  • Microbial Sensitivity Tests
  • Orthomyxoviridae (drug effects, pathogenicity, physiology)
  • Ribavirin (pharmacology)
  • Rimantadine (pharmacology)
  • Virus Replication (drug effects)

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