In vitro activity of HSR-903, a new oral quinolone, against bacteria causing respiratory infections.

Abstract

The in vitro activity of HSR-903, an oral quinolone, against 196 recent clinical isolates of respiratory pathogens was evaluated. HSR-903 was 2 to 32 times more active than ofloxacin, ciprofloxacin, and sparfloxacin against Staphylococcus aureus, including methicillin-resistant strains, and Streptococcus pneumoniae and was at least as active as the other quinolones against gram-negative pathogens.

• Authors: A Watanabe, Y Tokue, H Takahashi, T Kikuchi, T Kobayashi, K Gomi, S Fujimura, T Nukiwa
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 43 Issue 7 Pg. 1767-8 (Jul 1999) ISSN: 0066-4804 [Print] United States
• PMID: 10390240 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• Quinolones
• olamufloxacin

Topics

• Anti-Infective Agents (pharmacokinetics, pharmacology)
• Bacteria (drug effects)
• Fluoroquinolones
• Microbial Sensitivity Tests
• Quinolones (pharmacokinetics, pharmacology)
• Respiratory Tract Infections (microbiology)