[Pefloxacin in the treatment of the bone and joint infections].

Abstract

BACKGROUND:

To assess efficacy and tolerability of pefloxacin in association with other antibiotics in the treatment of acute and chronic bone and joint infections.

METHODS:

From January to December 1997, all the outpatients with diagnosis of acute or chronic bone and joint infections have been enrolled in a perspective study. If possible a cultural or histopathological study was performed. Treatment response was evaluated with radiological and clinical chemistry parameters.

RESULTS:

Fifteen patients [10 males, 5 females; mean age 40.7 +/- 15 years (range 15-71)] have been studied. They had 5 knee septic arthritis, 1 sacroileitis, 1 hip septic arthritis, 4 long bone osteomyelitis, 1 sterum osteomyelitis, 3 spondilitis. Three patients were HIV infected. Twelve were acute infections, 3 chronic ones. Overall, 7 were hematogenous infections, 6 subsequent to elective surgery, 1 post-traumatic thighbone osteomyelitis, 1 osteomyelitis by external fixation device. Isolates were S. aureus in 5 cases, P. mirabilis in 1 case, S. aureus+ Serratia marcescens in 1. In the remaining part cultural tests were negative. Pefloxacin was administered i.v. or orally at the dose of 400 mg/bid for a mean time of 114 +/- 74.5 days (range 30-270) in association with other chemotherapic agents. Ten good recoveries, 3 partial and 2 no responses were observed.

CONCLUSIONS:

Pefloxacin resulted to be useful in the treatment of acute and chronic bone and joint infections. No severe side effect was observed during the treatment.

• Authors: A Maiello, G Dassio, M M Calvo, A Gramoni
• Journal: Minerva medica (Minerva Med) 1999 Jan-Feb Vol. 90 Issue 1-2 Pg. 33-7 ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Pefloxacina nel trattamento delle infezioni dell'apparato osteoarticolare.
• PMID: 10388461 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Pefloxacin

Topics

• Adolescent
• Adult
• Aged
• Anti-Infective Agents (therapeutic use)
• Arthritis, Infectious (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Osteoarthritis (drug therapy, microbiology)
• Pefloxacin (therapeutic use)
• Prospective Studies