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Celsior solution for improvement of currently used clinical standards of lung preservation in an ex vivo rat model.

AbstractOBJECTIVE:
The introduction of Euro-Collins solution with its intracellular electrolyte composition has allowed for clinically accepted pulmonary preservation for up to 7 h of ischemic time. In recent years several alternative solutions have been developed for the improvement of pulmonary preservation. Celsior is an extracellular solution which has significantly reduced the ischemia/reperfusion (IR)-induced pulmonary damage in animal studies. So far, no larger experimental studies exist concerning the influence of Celsior on pulmonary gas exchange following IR.
METHODS:
In an extracorporeal rat lung model ten lungs, were each preserved with Celsior (CE) and Celsior/ prostacycline (CEPC, 6 mg/100 ml) at 4 degrees C and compared with preservation with low-potassium-Euro-Collins solution (LPEC, 40 mmol/l of potassium). After 2 h of ischemia the lungs were re-ventilated and reperfused using a roller-pump. Relative oxygenation capacity (ROC), pulmonary vascular resistance (PVR), peak inspiratory pressure (PIP) and wet/dry ratio were monitored for 50 min. Statistical analysis was performed using ANOVA.
RESULTS:
ROC was increased in all Celsior preserved organs compared with the EC group (P < 0.032). Though the CEPC group was found to have the lowest PIP and the least amount of lung water as assessed by wet/dry ratio, PVR was highest after 30-50 min. The significantly lowest PVR was determined in the CE group (P < 0.02).
CONCLUSIONS:
Celsior provides better lung preservation than LPEC solution, as demonstrated by a significantly increased oxygenation ability, a lower PVR and a decreased wet/ dry ratio. In vivo experiments and additional histological analysis are warranted for further evaluation of Celsior in lung preservation.
AuthorsT Wittwer, T Wahlers, J F Cornelius, S Elki, A Haverich
JournalEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (Eur J Cardiothorac Surg) Vol. 15 Issue 5 Pg. 667-71 (May 1999) ISSN: 1010-7940 [Print] Germany
PMID10386415 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Celsior
  • Disaccharides
  • Electrolytes
  • Glutamates
  • Organ Preservation Solutions
  • Mannitol
  • Histidine
  • Glutathione
Topics
  • Analysis of Variance
  • Animals
  • Disaccharides
  • Disease Models, Animal
  • Electrolytes
  • Extracorporeal Circulation
  • Glutamates
  • Glutathione
  • Histidine
  • Lung Transplantation (methods, physiology)
  • Male
  • Mannitol
  • Organ Preservation (standards)
  • Organ Preservation Solutions
  • Oxygen Consumption
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Sensitivity and Specificity
  • Vascular Resistance

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