Abstract | CASE REPORT: METHOD: Plasma and urine prothiofos and metabolites were detected by gas chromatography-flame photometry and gas chromatography-mass spectrometry. Two despropyl metabolites were synthesized for identification and estimation. RESULTS: The main metabolites were identified with authentic prothiofos and methyl esters of synthesized des-S-propyl prothiofos oxon (O-2,4-dichlorophenyl O-ethyl phosphate), despropyl prothiofos oxon (O-2,4-dichlorophenyl O-ethyl phospholothiolate), and des-S-propyl prothiofos (O-2,4-dichlorophenyl O-ethyl phosphorothioate). Despropyl prothiofos (O-2,4-dichlorophenyl O-ethyl phosphorodithioate) was also identified in plasma. Large amounts of the hydrolyzed product, 2,4-dichlorophenol and its conjugate were also found. The metabolic pattern of prothiofos in humans appears to be different from that in rats.
|
Authors | M Sakata, M Gotoh, K Ubukata, H Hayashi, M Kotaki, T Omote |
Journal | Journal of toxicology. Clinical toxicology
(J Toxicol Clin Toxicol)
Vol. 37
Issue 3
Pg. 327-32
( 1999)
ISSN: 0731-3810 [Print] United States |
PMID | 10384797
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Cholinesterase Inhibitors
- Insecticides
- Organothiophosphates
- Charcoal
- prothiophos
|
Topics |
- Charcoal
(therapeutic use)
- Cholinesterase Inhibitors
(blood, metabolism, poisoning, urine)
- Chromatography, Gas
- Female
- Gas Chromatography-Mass Spectrometry
- Humans
- Insecticides
(blood, metabolism, poisoning, urine)
- Methylation
- Middle Aged
- Organophosphate Poisoning
- Organothiophosphates
(blood, metabolism, urine)
|