Abstract | PURPOSE: Some authors postulate an avidity of certain porphyrin derivatives for tumors. The aim of this study was to examine the contrast enhancement of implanted melanotic melanoma after application of Mn-TPPS4 to achieve a better characterization of this malignant skin tumor. MATERIAL AND METHOD: High-resolution MR imaging (2.0 Tesla, 2.0-cm surface-coil, T1-weighted FLASH-2D-sequence) was performed on 15 mice (C57b16) with intracutaneous implanted melanoma (B16F1), before and after intravenous administration of either Gd-DTPA ( Magnevist, Schering, Berlin) as a reference contrast medium, or Mn-TPPS4 ( Porphyrin Products, Schering, Berlin). The images were evaluated quantitatively by calculating percentage enhancement, slope of signal intensity-to-time curves, percentage increase of the signal intensity, signal-to-noise and contrast-to-noise-ratios. The qualitative evaluation was accomplished by visual assessment of the enhancement, the demarcation of the tumors from the surrounding tissue and the homogeneity of the tumors. RESULTS: Contrast medium-enhanced images showed an increased signal intensity from all tumors with no signifikant difference between the contrast media. Demarcation of tumors from the surrounding tissue was better following administration of contrast media; regressive and altered areas was more clearly depicted. CONCLUSION:
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Authors | J Mäurer, A Strauss, W Ebert, H Bauer, R J Schroeder, R Felix |
Journal | Der Radiologe
(Radiologe)
Vol. 39
Issue 5
Pg. 422-7
(May 1999)
ISSN: 0033-832X [Print] Germany |
Vernacular Title | Mn-TPPS4 in der Diagnostik von malignen Hauttumoren. In-vivo-Untersuchungen mittels hochauflösender Magnetresonanztomographie an melanotischen Melanomen. |
PMID | 10384698
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Contrast Media
- Metalloporphyrins
- manganese(III)tetraphenylporphine sulfonate
- Gadolinium DTPA
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Topics |
- Animals
- Contrast Media
- Disease Models, Animal
- Gadolinium DTPA
- Humans
- Image Enhancement
- Magnetic Resonance Imaging
- Melanoma
(diagnosis)
- Metalloporphyrins
- Mice
- Skin Neoplasms
(diagnosis)
- Tomography
(methods)
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