Brain noradrenergic receptors in major depression and schizophrenia.

Abstract

The binding of [125I]p-iodoclonidine to alpha-2, and/or [125I]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (Brodmann's area 10) and right hippocampus from subjects with DSM-III-R diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as from control subjects (n = 20). No significant differences between study groups were observed in binding to alpha-2 adrenoceptors in any of the six layers of prefrontal cortex or in any of the hippocampal fields. Likewise, there were no significant differences in beta-1 or beta-2 adrenoceptor binding in any of the hippocampal fields between control and major depressive subjects. In contrast, binding to beta-1 adrenoceptors, but not beta-2 adrenoceptors, was significantly lower (-13 to -27%) in most hippocampal fields of schizophrenic subjects as compared to control subjects or to major depressives. Alterations in beta-1 adrenoceptor binding in the hippocampus of schizophrenics provide further evidence for a role of central noradrenergic neurons in the neurochemical pathology of schizophrenia.

• Authors: V Klimek, G Rajkowska, S N Luker, G Dilley, H Y Meltzer, J C Overholser, C A Stockmeier, G A Ordway
• Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology) Vol. 21 Issue 1 Pg. 69-81 (Jul 1999) ISSN: 0893-133X [Print] England
• PMID: 10379521 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adrenergic alpha-Agonists
• Adrenergic beta-Antagonists
• Affinity Labels
• Iodine Radioisotopes
• Receptors, Adrenergic
• 4-iodoclonidine
• 3-iodopindolol
• Pindolol
• Clonidine
• Norepinephrine

Topics

• Adrenergic alpha-Agonists
• Adrenergic beta-Antagonists
• Adult
• Affinity Labels
• Aged
• Autoradiography
• Brain Chemistry (physiology)
• Clonidine (analogs & derivatives)
• Depressive Disorder (metabolism)
• Female
• Hippocampus (metabolism)
• Humans
• Iodine Radioisotopes
• Male
• Middle Aged
• Norepinephrine (metabolism)
• Pindolol (analogs & derivatives)
• Prefrontal Cortex (metabolism)
• Receptors, Adrenergic (metabolism)
• Schizophrenia (metabolism)
• Suicide