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CP-10, a chemotactic peptide, is expressed in lesions of experimental autoimmune encephalomyelitis, neuritis, uveitis and in C6 gliomas.

Abstract
CP-10 (chemotactic protein of m.w. 10,000) is a member of the S100 superfamily of Ca2+ binding peptides, which has potent chemotactic activity for murine and human myeloid cells. Here we report on the generation of monoclonal antibodies against CP-10 and accumulation of CP-10+ cells during experimental autoimmune encephalomyelitis (EAE), neuritis (EAN), uveitis (EAU) and in experimentally transplanted C6 gliomas. During acute inflammation, CP-10 is mainly expressed by large ED1+ monocytic perivascular cells that accumulate at days 11-14. CP-10+ cells are predominantly located in areas of cellular infiltration but are as well found in the meninges and infiltrating the brain parenchyma. In transplanted gliomas, CP-10+ cells are located exclusively within the tumor parenchyma. Using double labeling experiments, other cells participating in the inflammatory reaction were found to express CP-10, like few lymphoblastic W3/13+ cells in the vicinity of the inflammatory infiltrate.
AuthorsM H Deininger, Y Zhao, H J Schluesener
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 93 Issue 1-2 Pg. 156-63 (Jan 01 1999) ISSN: 0165-5728 [Print] Netherlands
PMID10378879 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Calgranulin A
  • Chemotactic Factors
  • DNA Primers
  • Lymphocyte Function-Associated Antigen-1
  • Macrophage-1 Antigen
  • Recombinant Proteins
  • S100 Proteins
  • S100a8 protein, mouse
Topics
  • Animals
  • Antibodies, Monoclonal
  • Autoimmune Diseases (immunology)
  • Base Sequence
  • Calgranulin A
  • Chemotactic Factors (analysis, genetics, immunology)
  • Cloning, Molecular
  • DNA Primers
  • Encephalomyelitis, Autoimmune, Experimental (immunology)
  • Flow Cytometry
  • Gene Expression Regulation, Neoplastic (immunology)
  • Glioma
  • Hybridomas
  • Leukocytes (chemistry, immunology)
  • Lymphocyte Function-Associated Antigen-1 (analysis)
  • Macrophage-1 Antigen (analysis)
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Neuritis (immunology)
  • Rats
  • Rats, Inbred Lew
  • Recombinant Proteins (immunology)
  • S100 Proteins (analysis, genetics, immunology)
  • Spleen (cytology)
  • Tumor Cells, Cultured (immunology)
  • Uveitis (immunology)

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