Abstract | BACKGROUND: Epidemiologic data on human T-lymphotropic virus type I (HTLV-I) in Guadeloupe (French West Indies) are scant. STUDY DESIGN AND METHODS: From January 1989 to December 1996, 59,426 blood donors were screened by enzyme immunoassay for antibodies to HTLV-I. All repeatedly reactive samples were confirmed by Western blot. Temporal trends in HTLV-I seropositivity rates were examined during the study period. A multivariate analysis of donation, demographic, and biologic characteristics was performed. RESULTS: Of the screened blood donors, 195 were confirmed as seropositive, for an overall prevalence of 0.33 percent (95% CI 0.28-0.38). A marked decrease in overall HTLV-I prevalence with time (from 0.47% in 1989 to 0.13% in 1996) was observed, which can be explained mainly by the decreasing percentage of recruited new donors during the study period. Four independent risk factors for HTLV-I were identified: new donor status (odds ratio [OR] 12.5), female sex (OR 1.7), increasing age (30-39 years: OR, 2.4; 40-49 years: OR, 3.7; >50 years: OR 6.6), and positive antibodies to hepatitis B virus core antigen (OR, 1.7). Selection of specific locations for blood collection was inversely associated with HTLV-I (OR 0.5). CONCLUSION: New donor status, advancing age, female sex, and positivity for hepatitis B virus core antibodies were the major factors associated with HTLV-I infection in Guadeloupe.
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Authors | F Rouet, C Foucher, M Rabier, I Gawronski, D Taverne, B Chancerel, O Casman, M Strobel |
Journal | Transfusion
(Transfusion)
Vol. 39
Issue 6
Pg. 639-44
(Jun 1999)
ISSN: 0041-1132 [Print] United States |
PMID | 10378845
(Publication Type: Journal Article)
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Topics |
- Blood Donors
- HTLV-I Infections
(blood, transmission)
- Human T-lymphotropic virus 1
- Humans
- Multivariate Analysis
- Seroepidemiologic Studies
- West Indies
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