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Human T-lymphotropic virus type I among blood donors from Guadeloupe: donation, demographic, and biologic characteristics.

AbstractBACKGROUND:
Epidemiologic data on human T-lymphotropic virus type I (HTLV-I) in Guadeloupe (French West Indies) are scant.
STUDY DESIGN AND METHODS:
From January 1989 to December 1996, 59,426 blood donors were screened by enzyme immunoassay for antibodies to HTLV-I. All repeatedly reactive samples were confirmed by Western blot. Temporal trends in HTLV-I seropositivity rates were examined during the study period. A multivariate analysis of donation, demographic, and biologic characteristics was performed.
RESULTS:
Of the screened blood donors, 195 were confirmed as seropositive, for an overall prevalence of 0.33 percent (95% CI 0.28-0.38). A marked decrease in overall HTLV-I prevalence with time (from 0.47% in 1989 to 0.13% in 1996) was observed, which can be explained mainly by the decreasing percentage of recruited new donors during the study period. Four independent risk factors for HTLV-I were identified: new donor status (odds ratio [OR] 12.5), female sex (OR 1.7), increasing age (30-39 years: OR, 2.4; 40-49 years: OR, 3.7; >50 years: OR 6.6), and positive antibodies to hepatitis B virus core antigen (OR, 1.7). Selection of specific locations for blood collection was inversely associated with HTLV-I (OR 0.5).
CONCLUSION:
New donor status, advancing age, female sex, and positivity for hepatitis B virus core antibodies were the major factors associated with HTLV-I infection in Guadeloupe.
AuthorsF Rouet, C Foucher, M Rabier, I Gawronski, D Taverne, B Chancerel, O Casman, M Strobel
JournalTransfusion (Transfusion) Vol. 39 Issue 6 Pg. 639-44 (Jun 1999) ISSN: 0041-1132 [Print] United States
PMID10378845 (Publication Type: Journal Article)
Topics
  • Blood Donors
  • HTLV-I Infections (blood, transmission)
  • Human T-lymphotropic virus 1
  • Humans
  • Multivariate Analysis
  • Seroepidemiologic Studies
  • West Indies

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