Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay.

Abstract

In a search for anti-tumor-promoting agents, we carried out a primary screening of twenty-nine 8-substituted and four 6-substituted derivatives of 7-methoxycoumarins isolated from plants of the Murraya and/or Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. This investigation indicated that the prenyl (3-methyl-2-butenyl) or 2-hydroxy-3-methylbutyl (or butenyl) unit as an isoprenoid moiety at C-8 on the 7-methoxycoumarin nucleus plays an important role in the anti-tumor-promoting activity. Some of the 8-substituted 7-methoxycoumarins isolated from Murraya species, murrangatin (7), minumicrolin (10) and chloticol (18), were found to significantly inhibit EBV-EA activation, and preserved the high viability of Raji cells, suggesting that 7, 10 and 18 might be valuable anti-tumor-promoting agents.

• Authors: C Ito, M Itoigawa, H Furukawa, H Tokuda, Y Okuda, T Mukainaka, M Okuda, H Nishino
• Journal: Cancer letters (Cancer Lett) Vol. 138 Issue 1-2 Pg. 87-92 (Apr 26 1999) ISSN: 0304-3835 [Print] Ireland
• PMID: 10378778 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Coumarins
• Tetradecanoylphorbol Acetate

Topics

• Antineoplastic Agents (pharmacology)
• Cells, Cultured
• Coumarins (pharmacology)
• Herpesvirus 4, Human (drug effects, physiology)
• Humans
• Structure-Activity Relationship
• Tetradecanoylphorbol Acetate (antagonists & inhibitors)
• Virus Activation (drug effects)