The roles of RNA-binding proteins in spermatogenesis and male infertility.

Abstract

RNA-binding proteins are essential for spermatogenesis: they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men.

• Authors: J P Venables, I Eperon
• Journal: Current opinion in genetics & development (Curr Opin Genet Dev) Vol. 9 Issue 3 Pg. 346-54 (Jun 1999) ISSN: 0959-437X [Print] England
• PMID: 10377282 (Publication Type: Journal Article, Review)

Chemical References

• Nuclear Proteins
• RNA-Binding Proteins

Topics

• Animals
• Cytoplasm (metabolism)
• Humans
• Infertility, Male (physiopathology)
• Male
• Nuclear Proteins (physiology)
• RNA-Binding Proteins (physiology)
• Spermatogenesis (physiology)