HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antihyperlipidemic action of Ogi-Keishi-Gomotsu-To-Ka-Kojin against cyclophosphamide-induced hyperlipidemia in rabbits.

Abstract
The effect of Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK), a Japanese traditional herbal medicine (Kampo medicine), has been studied in a cyclophosphamide (CPM)-induced hyperlipidemia model in fasted rabbits. In this model, the accumulation of chylomicrons and very low density lipoprotein (VLDL) was known to occur as a result of a reduction in lipoprotein lipase (LPL) activity in the heart and heparin-releasable heart LPL. Oral administration of OKGK for 4 weeks was found to reverse the increase in serum triglycerides and cholesterol produced by CPM treatment especially in chyromicrons and VLDL. In addition, OKGK treatment led to a recovery in postheparin plasma LPL activity and heparin-releasable heart LPL activity which were reduced markedly by CPM treatment. We previously reported that OKGK increased LPL activity in postheparin plasma in rats. In this study, we have also found that OKGK improved hyperlipidemia in the CPM-induced hyperlipidemia model in rabbits, mainly due to an increase in heparin-releasable heart LPL activity and postheparin plasma LPL activity.
AuthorsM Inoue, C Z Wu, Y Ogihara
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 22 Issue 5 Pg. 486-90 (May 1999) ISSN: 0918-6158 [Print] Japan
PMID10375169 (Publication Type: Journal Article)
Chemical References
  • Anticholesteremic Agents
  • Drugs, Chinese Herbal
  • Insulin
  • ogi-keishi-gomotsu-to-ka-kojin
  • Cyclophosphamide
  • Heparin
  • Lipoprotein Lipase
Topics
  • Animals
  • Anticholesteremic Agents (therapeutic use)
  • Cyclophosphamide
  • Disease Models, Animal
  • Drugs, Chinese Herbal (therapeutic use)
  • Enzyme Activation
  • Heart (drug effects)
  • Heparin (pharmacology)
  • Hypercholesterolemia (chemically induced, drug therapy)
  • Hyperlipidemias (chemically induced, drug therapy)
  • Hypertriglyceridemia (chemically induced, drug therapy)
  • Insulin (blood)
  • Lipoprotein Lipase (metabolism)
  • Male
  • Myocardium (enzymology)
  • Phytotherapy
  • Rabbits

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: