Induction of presenilins in the rat brain after middle cerebral arterial occlusion.

Abstract

In the present study, we have examined the expression of both presenilins in the rat hippocampus, cortex, striatum, and cerebellum after middle cerebral artery occlusion (MCA-O), an animal model of ischemia. The cortex showed the greatest increase in PS mRNA levels (7-10-fold) at 4 and 8 days posttreatment. Presenilin-1 (PS-1) levels in the contralateral cortex were significantly increased 1 day after MCA-O. In comparison, PS mRNA content was only modestly elevated in the hippocampus and striatum at 4 and 8 days after MCA-O (30-100% changes). Other Alzheimer's disease (AD)-related genes, amyloid precursor protein and apolipoprotein E, are induced in brain injury suggesting that these AD-related genes may well be components of a brain-injury response. Thus, a breakdown in this response via cerebrovascular disease and/or genetic mutation may contribute to AD pathology.

• Authors: K R Pennypacker, H Hernandez, S Benkovic, D G Morgan, A E Willing, P R Sanberg
• Journal: Brain research bulletin (Brain Res Bull) Vol. 48 Issue 5 Pg. 539-43 (Mar 15 1999) ISSN: 0361-9230 [Print] United States
• PMID: 10372515 (Publication Type: Journal Article)

Chemical References

• Membrane Proteins
• Presenilin-1
• Presenilin-2

Topics

• Alzheimer Disease (genetics, metabolism)
• Animals
• Brain Ischemia (metabolism)
• Cerebral Arteries
• Gene Expression (physiology)
• Male
• Membrane Proteins (biosynthesis, genetics)
• Presenilin-1
• Presenilin-2
• Rats
• Rats, Sprague-Dawley