Abstract |
Randomly selected 34 cerebrovascular patients were treated with ethyl apovincaminate (RGH-4405, Cavinton) and 109 with xanitinol nicotinate. The effects of drugs given in slow i.v. infusions on the concentration of carbohydrate metabolites and electrolytes in serum and CSF were observed. Cavinton improved the paresis in 60.6% of patients while xantinol nicotinate did so only in 47.1%. On the basis of the biochemical changes it can be concluded that Cavinton enhances both the glycolytic and the oxidative glucose breakdown in CNS.
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Authors | B Vámosi, L Molnár, J Demeter, F Túry |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 26
Issue 10a
Pg. 1980-4
( 1976)
ISSN: 0004-4172 [Print] Germany |
PMID | 1037229
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Electrolytes
- Vinca Alkaloids
- Xanthinol Niacinate
- Theophylline
- Glucose
|
Topics |
- Brain
(metabolism)
- Cerebrovascular Disorders
(drug therapy, metabolism)
- Electrolytes
(metabolism)
- Glucose
(metabolism)
- Glycolysis
(drug effects)
- Humans
- Oxygen Consumption
(drug effects)
- Paralysis
- Theophylline
(analogs & derivatives)
- Vinca Alkaloids
(pharmacology)
- Xanthinol Niacinate
(pharmacology)
|