Gabapentin for self-injurious behavior in Lesch-Nyhan syndrome.

Abstract

Self-injurious behavior is a common clinical problem in children with Lesch-Nyhan syndrome, an X-linked disorder of purine metabolism. This behavior is not observed in other conditions associated with increased serum concentrations of uric acid, hypoxanthine, and xanthine. Various neurotransmitters appear to play a pivotal role in self-injurious behavior. The authors present a patient with Lesch-Nyhan syndrome, whose self-injurious behavior was effectively treated with gabapentin, and discuss possible mechanisms of action.

• Authors: J McManaman, D A Tam
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 20 Issue 5 Pg. 381-2 (May 1999) ISSN: 0887-8994 [Print] United States
• PMID: 10371385 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Acetates
• Amines
• Cyclohexanecarboxylic Acids
• GABA Agonists
• gamma-Aminobutyric Acid
• Gabapentin

Topics

• Acetates (therapeutic use)
• Amines
• Child, Preschool
• Cyclohexanecarboxylic Acids
• GABA Agonists (therapeutic use)
• Gabapentin
• Humans
• Lesch-Nyhan Syndrome (drug therapy)
• Male
• Self-Injurious Behavior (drug therapy)
• Treatment Outcome
• gamma-Aminobutyric Acid