HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Clinical efficacy of budipine in Parkinson's disease.

Abstract
The lipophilic t-butyl analog of 1-alkyl-4,4-diphenyl piperidine, budipine, possesses a polyvalent spectrum of mechanisms of action. Budipine experimentally increased the brain content of norepinephrine, serotonine, dopamine and histamine in reserpine treated rats. Budipine did not alter the receptor affinity of these neurotransmitters but antagonizes the effect of NMDA at its receptor binding site in vitro. Budipine reduced MPP+ toxicity in the nigrostriatal system of mice. This complex pharmacologic profile is not comparable to the one of convenient antiparkinsonian drugs. In clinical trials budipine reduced tremor, akinesia and rigidity. Budipine induced a relevant additional positive effect in patients with an optimal dopaminergic therapy based on levodopa and dopamine agonists, such as bromocriptine. Current available data suggest that the need for levodopa application in early stages of the disease may be postponed by budipine and that the long-term application of budipine may induce a levodopa-sparing effect.
AuthorsH Przuntek, T Müller
JournalJournal of neural transmission. Supplementum (J Neural Transm Suppl) Vol. 56 Pg. 75-82 ( 1999) ISSN: 0303-6995 [Print] Austria
PMID10370903 (Publication Type: Journal Article, Review)
Chemical References
  • Antiparkinson Agents
  • Piperidines
  • budipine
Topics
  • Animals
  • Antiparkinson Agents (pharmacology, therapeutic use)
  • Clinical Trials as Topic
  • Humans
  • Parkinson Disease (drug therapy)
  • Piperidines (pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: