Cerium-doped diosmectite for topical application studies of the cerium-clay interaction.

Abstract

Cerium is used for its antiseptic and immunomodulatory properties in burn injury. We have developed a cerium-doped clay to replace existing ointments. Adsorption and release of cerium (Ce3+) by diosmectite were studied at 22+/-2 degrees C, in the presence of various other cationic species. Simple spectrofluorimetric determination of cerium was used (lambdaexc=240 nm/lambdaem=360 nm). Cerium binding reached a plateau within 2 min and was a function of the electrolyte content of the solution in contact with the clay. Langmuir isotherm treatment led to a maximal binding capacity of 66 mg of Ce3+ per gram of clay. Partial release occurred within 2 min (19% in the presence of isotonic NaCl solution). The ionic strength of the solution, and the ionic radius and charge of the electrolytes present in the bathing solution significantly influenced cerium release, in contrast to pH and temperature changes. These results strongly point to a cationic exchange mechanism between diosmectite and cerium solution.

• Authors: N Papin-Castéla, P Prognon, F Keller, S Bénazeth, R Farinotti, G Mahuzier, C Souleau
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 181 Issue 2 Pg. 193-202 (Apr 30 1999) ISSN: 0378-5173 [Print] Netherlands
• PMID: 10370215 (Publication Type: Journal Article)
• Copyright: Copyright.

Chemical References

• Anti-Infective Agents, Local
• Electrolytes
• Gastrointestinal Agents
• Silicates
• Solutions
• Cerium
• Sodium Chloride
• Smectite

Topics

• Administration, Topical
• Adsorption
• Anti-Infective Agents, Local (administration & dosage, chemistry)
• Cerium (administration & dosage, chemistry)
• Electrolytes (chemistry)
• Fluorometry
• Gastrointestinal Agents (chemistry)
• Hydrogen-Ion Concentration
• Kinetics
• Silicates
• Sodium Chloride (chemistry)
• Solutions