Abstract | BACKGROUND: Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. AIMS: To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats. METHODS: Wistar rats, aged eight weeks, underwent 60% proximal resection or transection and received by orogastric intubation either 1 mg/g body wt per day lyophilised S boulardii or the vehicle for seven days. The effects on ileal mucosal adaptation were assessed eight days after surgery. RESULTS: Compared with transection, resection resulted in mucosal hyperplasia with significant decreases in the specific and total activities of sucrase, lactase, and maltase. Treatment of resected animals with S boulardii had no effect on mucosal hyperplasia but did upgrade disaccharidase activities to the levels of the transected group. Enzyme stimulation by S boulardii was associated with significant increases in diamine oxidase activity and mucosal polyamine concentrations. Likewise, sodium dependent D-glucose uptake by brush border membrane vesicles, measured as a function of time and glucose concentration in the incubation medium, was significantly (p<0.05) increased by 81% and three times respectively in the resected group treated with S boulardii. In agreement with this, expression of the sodium/ glucose cotransporter-1 in brush border membranes of resected rats treated with S boulardii was enhanced twofold compared with resected controls. CONCLUSION:
Oral administration of S boulardii soon after proximal enterectomy improves functional adaptation of the remnant ileum.
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Authors | J P Buts, N De Keyser, S Marandi, D Hermans, E M Sokal, Y H Chae, L Lambotte, H Chanteux, P M Tulkens |
Journal | Gut
(Gut)
Vol. 45
Issue 1
Pg. 89-96
(Jul 1999)
ISSN: 0017-5749 [Print] England |
PMID | 10369710
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Polyamines
- Disaccharidases
- Sodium-Potassium-Exchanging ATPase
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Topics |
- Adaptation, Physiological
- Animals
- Disaccharidases
(metabolism)
- Ileum
(enzymology, microbiology, physiopathology, surgery)
- Male
- Polyamines
(metabolism)
- Postoperative Care
(methods)
- Rats
- Rats, Wistar
- Saccharomyces
- Sodium-Potassium-Exchanging ATPase
(metabolism)
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