[Hyperreactive malarial splenomegaly in a European returning from Africa].

Hyper-reactive malarial splenomegaly (HMS) syndrome related to abnormal immunologic response to repeated malarial infections is unusual in European expatriates.
We report the case of a 72-year-old white male patient who had been residing in the Congo and developed a typical clinical features of hyperactive malarial syndrome characterized by massive splenomegaly with hypersplenism, high titers of malarial IgM antibodies, IgM macroglobulinemia, liver and medullary lymphocytic proliferation, and a clinical and immunological response to long-term chloroquine therapy.
Criteria for the diagnosis of hyper-reactive malarial splenomegaly are useful. However, making a distinction from malignant lymphoproliferative disorders is difficult, as a sustained response to chloroquine is required. Therefore, chloroquine appears to have a regulatory effect on the immune system.
AuthorsH Granier, R Vatan, X Nicolas, M Richecoeur, J Martin
JournalLa Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne (Rev Med Interne) Vol. 20 Issue 5 Pg. 431-3 (May 1999) ISSN: 0248-8663 [Print] FRANCE
Vernacular TitleSplénomégalie malarique hyperréactive chez un Européen revenant d'Afrique.
PMID10365415 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antibodies, Protozoan
  • Immunoglobulin M
  • Aged
  • Antibodies, Protozoan (blood)
  • Congo
  • France (ethnology)
  • Humans
  • Hypergammaglobulinemia (blood, immunology, parasitology)
  • Immunoglobulin M (blood)
  • Liver (immunology)
  • Lymphocyte Activation
  • Malaria (complications, immunology)
  • Male
  • Spleen (immunology, pathology)
  • Splenomegaly (immunology, parasitology)

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