Abstract | BACKGROUND AND OBJECTIVE: METHODS: The effects of reproterol, orciprenaline and theophylline (10(-9)-10(-5) M) on spontaneous cAMP (5 x 10(4) cells/30 min)- and on LPS (10 microg/ml)-stimulated LTB4 production (10(5) cells/4 h) were determined in normal monocytes in vitro. RESULTS: CONCLUSION: We conclude that reproterol exerts a strong stimulatory effect on monocyte cAMP production and a suppressive effect on LTB4 production possibly due to a synergistic mode of action on adenylate cyclase activity and inhibition of phosphodiesterases. More clinical studies in bronchial asthma will be needed to determine whether these results may translate into clinically relevant effects.
|
Authors | U R Juergens, M Stöber, H Vetter |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 66
Issue 3
Pg. 220-4
( 1999)
ISSN: 0025-7931 [Print] Switzerland |
PMID | 10364737
(Publication Type: Comment, Journal Article)
|
Chemical References |
- Adrenergic beta-Agonists
- Adrenergic beta-Antagonists
- Bronchodilator Agents
- Drug Combinations
- reproterol
- Leukotriene B4
- Metaproterenol
- Theophylline
- Cyclic AMP
|
Topics |
- Adrenergic beta-Agonists
(pharmacology)
- Adrenergic beta-Antagonists
(pharmacology)
- Adult
- Bronchodilator Agents
(pharmacology)
- Cyclic AMP
(biosynthesis)
- Drug Combinations
- Humans
- Leukotriene B4
(biosynthesis)
- Metaproterenol
(analogs & derivatives, pharmacology)
- Reference Values
- Theophylline
(analogs & derivatives, pharmacology)
|