HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Topical netilmicin compared with tobramycin in the treatment of external ocular infection.

Abstract
In a pilot double-blind, randomized, prospective controlled study the effectiveness and safety of 0.3% netilmicin ophthalmic solution were compared with those of 0.3% tobramycin in treating external bacterial ocular infections in 45 eligible patients. The treatment with both study medications resulted in a significant (p < 0.001, Wilcoxon test) reduction in the mean cumulative score of the signs and symptoms. However, no statistically significant differences were observed between the two groups. The clinical improvement rate was almost complete with either antibiotics. There was a statistically positive trend in the netilmicin group with regard to the microbiological improvement that was achieved in (87% of the netilmicin patients) compared with 77% of the tobramycin patients (77%). Antibiotic sensitivity revealed that 84% of the organisms isolated were sensitive to netilmicin whereas only 64% of them were sensitive to tobramycin. Only minor adverse events occurred in patients treated with either netilmicin or tobramycin. In conclusion, this study demonstrates that netilmicin is a promising new antibiotic for treating external ocular infections.
AuthorsG Milazzo, V Papa, B Carstocea, G Chercota, P Rodica, O Gafencu, M Santocono
JournalInternational journal of clinical pharmacology and therapeutics (Int J Clin Pharmacol Ther) Vol. 37 Issue 5 Pg. 243-8 (May 1999) ISSN: 0946-1965 [Print] Germany
PMID10363623 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Gentamicins
  • Netilmicin
  • Tobramycin
Topics
  • Administration, Topical
  • Adult
  • Anti-Bacterial Agents (therapeutic use)
  • Conjunctivitis, Bacterial (drug therapy, microbiology)
  • Double-Blind Method
  • Drug Resistance, Microbial
  • Female
  • Gentamicins (therapeutic use)
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Netilmicin (therapeutic use)
  • Staphylococcal Infections (drug therapy, microbiology)
  • Staphylococcus aureus (drug effects)
  • Tobramycin (therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: