Abstract | OBJECTIVE: To find the efficacy and optimal dosage of oxybutynin HC1 in a group of enuretic children, who were non-responsive to imipramine. MATERIAL AND METHODS: Thirty-six patients with enuresis who were non-responsive to imipramine were urodynamically assessed and subsequently treated with oxybutynin hydrochloride (HCl). Patients with inadequate bladder storage function (IBSF) were started on 10-mg daily oxybutynin HCl for one month. If the initial treatment was found to be inadequate, the dose was increased to 15 mg daily. The dose in patients who were non-responsive to 15-mg daily dose was increased to 20-mg daily dose. Patients who were normal urodynamically were treated with a dose of 15 mg daily for one month. RESULTS: Before the treatment, 17 patients had IBSF (47.2%). The majority of the patients (88.2%) with IBSF were responsive to the 15-mg daily oxybutynin HCl. The treatment in patients with normal bladder function was generally unsuccessful. CONCLUSIONS:
Oxybutynin HCl in sufficient dosages seems to be effective in the treatment of enuretic patients with IBSF.
|
Authors | A Koşar, N Arikan, C Dinçel |
Journal | Scandinavian journal of urology and nephrology
(Scand J Urol Nephrol)
Vol. 33
Issue 2
Pg. 115-8
(Apr 1999)
ISSN: 0036-5599 [Print] England |
PMID | 10360452
(Publication Type: Journal Article)
|
Chemical References |
- Cholinergic Antagonists
- Mandelic Acids
- oxybutynin
|
Topics |
- Adolescent
- Child
- Cholinergic Antagonists
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Enuresis
(drug therapy)
- Humans
- Mandelic Acids
(administration & dosage, therapeutic use)
- Time Factors
- Urodynamics
(drug effects)
|