Abstract |
123I-iodophenyl-9-methyl-pentadecanoic acid ( 9MPA) is a modified long-chain (15 carbons) fatty acid with a methyl branch on its 9 carbon location. Myocardial SPECT images (two sets, 10 min each) were obtained starting 10 min (early phase) and 50 min (delay phase) after the injection of 160 MBq 123I-9MPA at rest in 10 patients with acute myocardial infarction. The segmental myocardial uptake (% uptake) and clearance (% washout) from early to delay image were calculated by the SPECT data. ECG-gated myocardial SPECT with 99mTc-sestamibi was also performed and segmental left ventricular (LV) wall motion was evaluated using QGS (quantitative gated SPECT) program. The % uptake of LV segments with hypokinetic or akinetic wall motion were significantly lower than those with normokinesis (p < 0.01) for both early and delay phases. The % washout of hypokinetic segments were significantly lower than those of normokinetic regions (p < 0.01), while the % washout of akinetic segments were significantly higher than those of severely hypokinetic segments (p < 0.05). Thus, 123I-9MPA myocardial distribution and clearance thought to be associated with left ventricular regional wall motion.
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Authors | S Kumita, T Kijima, H Nakajo, K Cho, S Mizumura, T Kumazaki, J Sano, Y Tada, Y Kusama, K Munakata, H Kishida |
Journal | Kaku igaku. The Japanese journal of nuclear medicine
(Kaku Igaku)
Vol. 36
Issue 3
Pg. 241-8
(Apr 1999)
ISSN: 0022-7854 [Print] Japan |
PMID | 10358959
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Fatty Acids
- Iodine Radioisotopes
- Iodobenzenes
- iodofiltic acid
- Technetium Tc 99m Sestamibi
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Topics |
- Fatty Acids
- Humans
- Iodine Radioisotopes
- Iodobenzenes
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, physiopathology)
- Technetium Tc 99m Sestamibi
- Tomography, Emission-Computed, Single-Photon
- Ventricular Function, Left
(physiology)
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