Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream.

Abstract	The prevalence of onychomycosis, a superficial fungal infection that destroys the entire nail unit, is rising, with no satisfactory cure. The objective of this randomized, double-blind, placebo-controlled study was to examine the clinical efficacy and tolerability of 2% butenafine hydrochloride and 5% Melaleuca alternifolia oil incorporated in a cream to manage toenail onychomycosis in a cohort. Sixty outpatients (39 M, 21 F) aged 18-80 years (mean 29.6) with 6-36 months duration of disease were randomized to two groups (40 and 20), active and placebo. After 16 weeks, 80% of patients using medicated cream were cured, as opposed to none in the placebo group. Four patients in the active treatment group experienced subjective mild inflammation without discontinuing treatment. During follow-up, no relapse occurred in cured patients and no improvement was seen in medication-resistant and placebo participants.
Authors	T A Syed, Z A Qureshi, S M Ali, S Ahmad, S A Ahmad
Journal	Tropical medicine & international health : TM & IH (Trop Med Int Health) Vol. 4 Issue 4 Pg. 284-7 (Apr 1999) ISSN: 1360-2276 [Print] England
PMID	10357864 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References	Anti-Infective Agents, Local Antifungal Agents Benzylamines Drug Combinations Naphthalenes Oils, Volatile Ointments Plant Oils Tea Tree Oil butenafine
Topics	Administration, Topical Adolescent Adult Aged Aged, 80 and over Anti-Infective Agents, Local (therapeutic use) Antifungal Agents (therapeutic use) Benzylamines (therapeutic use) Debridement Double-Blind Method Drug Combinations Female Foot Dermatoses (diagnosis, drug therapy, microbiology) Humans Male Middle Aged Naphthalenes (therapeutic use) Oils, Volatile (therapeutic use) Ointments Onychomycosis (diagnosis, drug therapy, microbiology) Plant Oils (therapeutic use) Tea Tree Oil Treatment Outcome

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