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Elevated plasma levels of S-100b protein in schizophrenic patients.

AbstractBACKGROUND:
In this study, we examined the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia.
METHODS:
We compared plasma levels of S-100b protein in 20 patients with schizophrenic psychosis and 20 age- and gender-matched healthy blood donors. Concentrations of S-100 protein were determined by microtiter-based immunofluorometric assay detecting predominantly S-100b.
RESULTS:
Mean concentrations of S-100b protein in blood were significantly (p < or = .001) higher in schizophrenic patients (0.165 +/- 0.138 microgram/L) compared to control subjects (0.054 +/- 0.031 microgram/L). Levels did not correlate with age of onset or duration of psychosis.
CONCLUSIONS:
Our findings indicate that patients with schizophrenia may suffer ongoing structural damage to cells of the central nervous system, and that the concentration of S-100b protein in plasma may help to identify clinical subgroups in schizophrenia.
AuthorsM Wiesmann, K P Wandinger, U Missler, D Eckhoff, M Rothermundt, V Arolt, H Kirchner
JournalBiological psychiatry (Biol Psychiatry) Vol. 45 Issue 11 Pg. 1508-11 (Jun 1 1999) ISSN: 0006-3223 [Print] UNITED STATES
PMID10356634 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
Topics
  • Adult
  • Biomarkers (blood)
  • Brain (physiopathology)
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Degeneration (blood)
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins (blood)
  • Schizophrenia (blood, physiopathology)

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