| Abstract | The relationship between ocular toxoplasmosis and levels of toxoplasma specific antibodies was examined in 195 patients. Using clinical information collected by questionnaires, patients were divided into: 97 with ocular toxoplasmosis (group 1) and 98 with ocular lesions not due to toxoplasma (group 2). The geometric mean of dye test titres (+/-S.D. natural log titre) in group 1 was 53.2 (+/-0.95) compared with 24.6 (+/-1.11) in group 2 (P < 0.001). Young females tended to have more active lesions compared with young males (P < 0.05). There was an age-dependent difference in dye test titres between the groups (P < 0.001). Group 1 showed a decline in titre with age compared with an increase in group 2. Ocular toxoplasmosis was diagnosed most frequently among 21-30 year olds. More group 1 patients had dye test titres > or = 65 iu/ml than group 2 (P < 0.05). Dye test titres > or = 65 iu/ml support a diagnosis of ocular toxoplasmosis whereas lower titres suggest other causes for eye lesions. |
| Authors | D J Chapman, D Ashburn, S A Ogston, D O Ho-Yen
(Affiliation: Scottish Toxoplasma Reference Laboratory, Microbiology Department, Raigmore Hospital NHS Trust, Inverness.)
|
| Journal | Epidemiology and infection
(Epidemiol Infect)
Vol. 122
Issue 2
Pg. 299-303
(Apr 1999)
ISSN: 0950-2688 ENGLAND |
| PMID | 10355796
(Publication Type: Journal Article)
|
| Chemical References |
- Antibodies, Protozoan
- Coloring Agents
|
| Topics |
- Adolescent
- Adult
- Age Distribution
- Aged
- Animals
- Antibodies, Protozoan
(blood)
- Child
- Child, Preschool
- Coloring Agents
- Female
- Humans
- Male
- Middle Aged
- Sex Distribution
- Toxoplasma
(immunology)
- Toxoplasmosis, Ocular
(diagnosis, epidemiology, immunology)
|
